Writer : Endy Adnan
(supervised by Edu S Tehupeiory)
Background. Intercritical gout arthritis is an acute gout in intermittent period, caused by inflammation process neither with tofus. Inflammation is a complex mechanism among pathogenic agents, parenchymal cell, tissue and blood vessels either with plasma or blood cellular. Inflammation induced by uric crystal in the joint is a patomechanismin gout arthritis and than activated and release celluler, humoral or complement mediators. The aim of this study to investigatigate the value of leucocyte, ESR, CRP, C3 components and C4 components in intercritical gout arthritis.
Subject and Method. This is an observational study with case control approach conducted in 20 subjects with intercritical gout arthritis (case) and 20 with asymptomatic hyperuricemia (control). Eclusioc criteria were rheumatoid arthritis, septic arthritis, psoriatic arthritis, osteoarthritis, chronic infection disease, and history of trauma, diagnosed as anemia, chronic kidney disease, malignancies, during consumption diuretics or AINS.
Result. We found mean age 54,93 year old, uric acid 9,445 mg/dl, 5 with positif CRP. Mean value of leucocyte both case and control were 9988,25 +- 2819,936 / mm3 vs 9540,5 +- 2333,656 / mm3 (p=0,153). No correlation between intercritial gout arthritis and the higher value of leucocyte (p=0,11), (OR 1.625; Cl 0.869-3.038). Mean value of ESR were 58,70 +- 12,650 vs 36,75 +- 7,587212 (p=0.343) and the statistical correlation between value of C4 and intercrtitical gout arthritis was uncalculated because of invariant data.
Conclusion. The higher value of ESR and CRP were correlated in intercritical gout arthritis comparing with asymtomatic hyperuricemia, while leucocyte, C3 and C4 were not correlated.
Subject and Method. This is an observational study with case control approach conducted in 20 subjects with intercritical gout arthritis (case) and 20 with asymptomatic hyperuricemia (control). Eclusioc criteria were rheumatoid arthritis, septic arthritis, psoriatic arthritis, osteoarthritis, chronic infection disease, and history of trauma, diagnosed as anemia, chronic kidney disease, malignancies, during consumption diuretics or AINS.
Result. We found mean age 54,93 year old, uric acid 9,445 mg/dl, 5 with positif CRP. Mean value of leucocyte both case and control were 9988,25 +- 2819,936 / mm3 vs 9540,5 +- 2333,656 / mm3 (p=0,153). No correlation between intercritial gout arthritis and the higher value of leucocyte (p=0,11), (OR 1.625; Cl 0.869-3.038). Mean value of ESR were 58,70 +- 12,650 vs 36,75 +- 7,587212 (p=0.343) and the statistical correlation between value of C4 and intercrtitical gout arthritis was uncalculated because of invariant data.
Conclusion. The higher value of ESR and CRP were correlated in intercritical gout arthritis comparing with asymtomatic hyperuricemia, while leucocyte, C3 and C4 were not correlated.
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