Association Between C-Reactive Protein Level and Components of the Metabolic Syndrome

Writer : Daniel Josten
(supervised by John M.F. Adam)

Association between C-reactive protein, a sensitive marker for inlammation, and the development of atherosclerosis disease had been observed in experimental and epidemological studies. Interest in CRP was increased along with problem of metabolic syndrome because basically all components of metabolic syndrome were inflammation process. In Indonesia, the same study was so limited, eventhough according to WHO prevelance of obesity was increased in developing countries so do in developed countries wich will increase the metabolic syndrome population. The aim of this study is to know association between CRP level and components of metabolic syndrome. We studied 138 apparently health subjects aged 35-65 years old whoparticipated in the East Indonesia Diabetes Epidemiology Group (EIDEG) in November 2005 until January 2007. Method in this study was observational study with cross sectional approach. Anamnesis and complete physical examintaion was performed to all subjects included blood pressure and waist circumference. After 12-h fasting, blood was taken for fasting plasma glucose (FPG), HDL-cholesterol, triglyseride and C-reactive protein (CRP). For the diagnosis of Mets we used criteria defined by the International Diabetes Federation (IDF) 2005. The result of this study showed there were a statistically significant positive correlation between CRP and waist circumference (r=0.1), TG (r=0.3), FPG (r=0.2), blood pressure (r=0.3) (all p<0.05). A negative correlation was found between CRP and HDL cholesterol (r=0.3) (p=0.02). Mean CRP levelth 0 components of the metabolic syndrome were 1.04, 1.52, 3.15, 4.21, 4.65, and 6.33 mg/l respectively (r=0.54, p <0.0001). From this study we concluded that CRP leel were associated with components of metabolic syndrome.

Posted in: C-reactive protein,inflammation,metabolic syndrome