Writer :Himawan Dharmayani Sanusi
(supervised by John MF Adam, A. Fachruddin Benyamin)
Plasminogen activator inhibitor-1 is an acute phase protein that regulate fibrinolysis from hemostatic process and plays an important role in the pathogenesis of atherothrombosis. Subject with metabolic syndrome are high risk of cardiovascular complication. The aim of this study is to find out of relation between PAI-1 and the component of metabolic syondrome. In this study, we enrolled subject of age varied from 30 – 65 years. Those with diabetes mellitus, and clinical cardiovascular complications were excluded. History taking and complete physical examinations were performed to all subject. After 12 hour fasting,blood was taken for the examinations of fasting HDL –cholestrol ,triglyceride fasting flasma glucose and PAI -1.PAI -1 was measured by sensitive enzyme immunoassay technique for the diagnosis of metabolic syndrome, the AHA/NHLBI guideline was used with the modification of waist circumeference fro Asian population.Statistical analysis using SPSS 12 for windows.
During the study,183 subjects can be covered , 41% males and 59 % females. PAI – 1 levels was statistical significant higner among patients with metabolic syndrome compared to normal subjects,18.01 ± 9.33 mlU/ml and 4.33± 4.83 mlU/ml subsequently [ P= 0.000 ] . there was significant positive correlation between fasting hyperglycemia , triglycerides,waist circumference,blood pressure with increased of PAI – 1 and significant negatife correlation between HDL – chosterol with increased levels of PAI – 1 [p<> 7 IU /ml as a high level,statistical analysis showed that subjects with high trigly cerydes had the higner risk for hig PAI – 1 activity compared to correlation between the componenst of metabolic syndrome with the increasing of PAI – 1 levels, being the highest among those with five components .[r =0.828 and p=0.000]
In conclusion , there was a corelation between the components of metabolic syndrome and levels of plasminogen activator inhibitor – 1 those with hypetriglycerides had the highest risk to have high levels of plasminogen activator inhibitor – 1.
Posts
0 comments:
Post a Comment