Value of Inflammation Marker in Patients with Intercritical Gout Arthritis

Writer : Endy Adnan
(supervised by Edu S Tehupeiory)

Background. Intercritical gout arthritis is an acute gout in intermittent period, caused by inflammation process neither with tofus. Inflammation is a complex mechanism among pathogenic agents, parenchymal cell, tissue and blood vessels either with plasma or blood cellular. Inflammation induced by uric crystal in the joint is a patomechanismin gout arthritis and than activated and release celluler, humoral or complement mediators. The aim of this study to investigatigate the value of leucocyte, ESR, CRP, C3 components and C4 components in intercritical gout arthritis.
Subject and Method. This is an observational study with case control approach conducted in 20 subjects with intercritical gout arthritis (case) and 20 with asymptomatic hyperuricemia (control). Eclusioc criteria were rheumatoid arthritis, septic arthritis, psoriatic arthritis, osteoarthritis, chronic infection disease, and history of trauma, diagnosed as anemia, chronic kidney disease, malignancies, during consumption diuretics or AINS.
Result. We found mean age 54,93 year old, uric acid 9,445 mg/dl, 5 with positif CRP. Mean value of leucocyte both case and control were 9988,25 +- 2819,936 / mm3 vs 9540,5 +- 2333,656 / mm3 (p=0,153). No correlation between intercritial gout arthritis and the higher value of leucocyte (p=0,11), (OR 1.625; Cl 0.869-3.038). Mean value of ESR were 58,70 +- 12,650 vs 36,75 +- 7,587212 (p=0.343) and the statistical correlation between value of C4 and intercrtitical gout arthritis was uncalculated because of invariant data.
Conclusion. The higher value of ESR and CRP were correlated in intercritical gout arthritis comparing with asymtomatic hyperuricemia, while leucocyte, C3 and C4 were not correlated.

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Association Between C-Reactive Protein Level and Components of the Metabolic Syndrome

Writer : Daniel Josten
(supervised by John M.F. Adam)

Association between C-reactive protein, a sensitive marker for inlammation, and the development of atherosclerosis disease had been observed in experimental and epidemological studies. Interest in CRP was increased along with problem of metabolic syndrome because basically all components of metabolic syndrome were inflammation process. In Indonesia, the same study was so limited, eventhough according to WHO prevelance of obesity was increased in developing countries so do in developed countries wich will increase the metabolic syndrome population. The aim of this study is to know association between CRP level and components of metabolic syndrome. We studied 138 apparently health subjects aged 35-65 years old whoparticipated in the East Indonesia Diabetes Epidemiology Group (EIDEG) in November 2005 until January 2007. Method in this study was observational study with cross sectional approach. Anamnesis and complete physical examintaion was performed to all subjects included blood pressure and waist circumference. After 12-h fasting, blood was taken for fasting plasma glucose (FPG), HDL-cholesterol, triglyseride and C-reactive protein (CRP). For the diagnosis of Mets we used criteria defined by the International Diabetes Federation (IDF) 2005. The result of this study showed there were a statistically significant positive correlation between CRP and waist circumference (r=0.1), TG (r=0.3), FPG (r=0.2), blood pressure (r=0.3) (all p<0.05). A negative correlation was found between CRP and HDL cholesterol (r=0.3) (p=0.02). Mean CRP levelth 0 components of the metabolic syndrome were 1.04, 1.52, 3.15, 4.21, 4.65, and 6.33 mg/l respectively (r=0.54, p <0.0001). From this study we concluded that CRP leel were associated with components of metabolic syndrome.

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